Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12580.152 | 1.0064 | 1.0057 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12580.152 | 0.9935 | 0.9943 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12580.152 | 0.8734 | 0.8837 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12580.152 | 0.1510 | -0.1336 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12580.152 | 0.2110 | 0.0046 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12580.152 | 0.1348 | -0.1760 | 2.2597 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11056.152 | 0.9672 | 0.9777 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11056.152 | 1.0099 | 1.0066 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11056.152 | 0.9947 | 0.9964 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11056.152 | 1.0487 | 1.0322 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11056.152 | 1.0492 | 1.0325 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11056.152 | 1.0368 | 1.0245 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11056.152 | 0.4517 | 0.5311 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11056.152 | 0.0259 | -0.4144 | 2.9748 | |
| MCF 10A | NM | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11056.152 | 0.0223 | -0.4430 | 2.9748 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12254.152 | 1.0037 | 1.0040 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12254.152 | 0.9891 | 0.9881 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12254.152 | 0.9811 | 0.9794 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12254.152 | 0.9761 | 0.9739 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12254.152 | 1.0628 | 1.0674 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12254.152 | 1.1747 | 1.1831 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12254.152 | 0.8394 | 0.8183 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12254.152 | 0.1111 | -0.3949 | 1.8382 | |
| MCF 10F | NM | - | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12254.152 | 0.0450 | -0.6299 | 1.8382 | |
| MCF12A | NM | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10817.152 | 0.9910 | 0.9875 | 1.4414 |