Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12400.152 | 0.5086 | 0.1049 | 1.1392 | |
| HCC70 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12400.152 | 0.0747 | -0.7949 | 1.1392 | |
| HCC70 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12400.152 | 0.0181 | -0.9409 | 1.1392 | |
| HCC70 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12400.152 | 0.0181 | -0.9409 | 1.1392 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10694.152 | 1.0038 | 1.0031 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10694.152 | 0.9758 | 0.9799 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10694.152 | 0.9375 | 0.9474 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10694.152 | 0.9743 | 0.9786 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10694.152 | 0.9798 | 0.9832 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10694.152 | 0.8819 | 0.8989 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10694.152 | 0.3513 | 0.2989 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10694.152 | 0.1101 | -0.1952 | 2.4238 | |
| Hs 578T | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10694.152 | 0.0350 | -0.4983 | 2.4238 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10816.152 | 0.9588 | 0.9186 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10816.152 | 0.9126 | 0.8270 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10816.152 | 0.9204 | 0.8426 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10816.152 | 0.9645 | 0.9298 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10816.152 | 0.8947 | 0.7917 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10816.152 | 0.7046 | 0.4146 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10816.152 | 0.3607 | -0.2706 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10816.152 | 0.0147 | -0.9693 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10816.152 | 0.0123 | -0.9742 | 1.0111 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12580.152 | 0.9794 | 0.9816 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12580.152 | 0.9886 | 0.9899 | 2.2597 | |
| MB 157 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12580.152 | 0.9927 | 0.9936 | 2.2597 |