Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7907.043 | 0.8879 | 0.8595 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7907.043 | 0.9361 | 0.9207 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7907.043 | 0.8277 | 0.7813 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7907.043 | 0.8077 | 0.7549 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7907.043 | 0.8051 | 0.7513 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7907.043 | 0.5708 | 0.4187 | 1.6330 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9759.121 | 1.0217 | 1.0336 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9759.121 | 0.9883 | 0.9819 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9759.121 | 0.8032 | 0.6873 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9759.121 | 0.4023 | -0.0135 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9759.121 | 0.1994 | -0.4277 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9759.121 | 0.0809 | -0.7157 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9759.121 | 0.0980 | -0.6701 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9759.121 | 0.0551 | -0.7891 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9759.121 | 0.0334 | -0.8569 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9760.121 | 1.1055 | 1.2052 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9760.121 | 0.8388 | 0.6853 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9760.121 | 0.7108 | 0.4341 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9760.121 | 0.6820 | 0.3775 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9760.121 | 0.5070 | 0.0320 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9760.121 | 0.2893 | -0.4026 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9760.121 | 0.2184 | -0.5456 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9760.121 | 0.2233 | -0.5357 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9760.121 | 0.1220 | -0.7425 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 10127.121 | 1.0242 | 1.0436 | 1.1088 |