Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12206.159 | 0.7983 | 0.6216 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12206.159 | 0.3261 | -0.2953 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12206.159 | 0.3185 | -0.3107 | 1.0742 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12594.152 | 1.0570 | 1.0866 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12594.152 | 1.0591 | 1.0897 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12594.152 | 1.0534 | 1.0811 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12594.152 | 1.0466 | 1.0709 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12594.152 | 1.0650 | 1.0985 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12594.152 | 0.2458 | -0.3157 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12594.152 | 0.1218 | -0.5999 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12594.152 | 0.0277 | -0.8711 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12594.152 | 0.0153 | -0.9179 | 1.3085 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10642.14 | 0.9560 | 0.8421 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10642.14 | 0.8990 | 0.6465 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10642.14 | 0.9211 | 0.7211 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10642.14 | 0.9959 | 0.9849 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10642.14 | 0.9537 | 0.8341 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10642.14 | 0.9307 | 0.7540 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10642.14 | 0.8318 | 0.4284 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10642.14 | 0.7248 | 0.1108 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10642.14 | 0.6231 | -0.1574 | 0.5473 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10818.152 | 0.9860 | 0.9389 | 0.4535 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10818.152 | 0.9634 | 0.8422 | 0.4535 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10818.152 | 0.9650 | 0.8489 | 0.4535 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10818.152 | 0.9812 | 0.9179 | 0.4535 |