Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12000.159 | 0.0534 | -0.9026 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12084.159 | 0.9480 | 0.9149 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12084.159 | 0.9619 | 0.9378 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12084.159 | 1.0678 | 1.1095 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12084.159 | 1.0206 | 1.0334 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12084.159 | 0.7925 | 0.6553 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12084.159 | 0.5505 | 0.2308 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12084.159 | 0.2263 | -0.4029 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12084.159 | 0.0551 | -0.8109 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12084.159 | 0.0054 | -0.9712 | 1.2294 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12001.159 | 0.9310 | 0.8086 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12001.159 | 0.9983 | 0.9953 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12001.159 | 0.9791 | 0.9413 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12001.159 | 0.9275 | 0.7990 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12001.159 | 0.9331 | 0.8144 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12001.159 | 0.9720 | 0.9218 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12001.159 | 0.7541 | 0.3446 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12001.159 | 0.3526 | -0.5386 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12001.159 | 0.3037 | -0.6261 | 0.7107 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10693.152 | 0.9837 | 0.9627 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10693.152 | 0.9503 | 0.8866 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10693.152 | 0.9728 | 0.9378 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10693.152 | 0.9407 | 0.8648 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10693.152 | 0.9854 | 0.9666 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10693.152 | 0.9419 | 0.8675 | 0.8734 |