Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10693.152 | 0.5499 | 0.0084 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10693.152 | 0.1007 | -0.8555 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10693.152 | 0.0981 | -0.8598 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11936.159 | 1.0282 | 1.0759 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11936.159 | 0.9153 | 0.7765 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11936.159 | 1.0142 | 1.0381 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11936.159 | 1.0121 | 1.0324 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11936.159 | 0.9808 | 0.9488 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11936.159 | 0.9651 | 0.9071 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11936.159 | 0.5251 | -0.1554 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11936.159 | 0.0884 | -0.9222 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11936.159 | 0.0256 | -0.9852 | 0.7472 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10872.152 | 0.9633 | 0.9536 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10872.152 | 0.9534 | 0.9409 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10872.152 | 0.9518 | 0.9389 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10872.152 | 0.9630 | 0.9532 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10872.152 | 0.8893 | 0.8579 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10872.152 | 0.8574 | 0.8158 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10872.152 | 0.2231 | -0.2206 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10872.152 | 0.1357 | -0.4297 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10872.152 | 0.1636 | -0.3586 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12523.152 | 1.0205 | 1.0487 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12523.152 | 0.9874 | 0.9701 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12523.152 | 1.0436 | 1.1039 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12523.152 | 1.0347 | 1.0826 | 0.8423 |