Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12523.152 | 1.0415 | 1.0990 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12523.152 | 1.0123 | 1.0294 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12523.152 | 0.2275 | -0.6552 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12523.152 | 0.3128 | -0.4968 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12523.152 | 0.1716 | -0.7533 | 0.8423 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12239.152 | 0.9459 | 0.9503 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12239.152 | 0.9998 | 0.9998 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12239.152 | 0.9477 | 0.9520 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12239.152 | 1.0019 | 1.0018 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12239.152 | 0.8787 | 0.8864 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12239.152 | 0.9263 | 0.9319 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12239.152 | 0.1286 | -0.2092 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12239.152 | 0.0301 | -0.5902 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12239.152 | 0.0188 | -0.6688 | 2.2104 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11849.159 | 0.9490 | 0.9179 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11849.159 | 0.9214 | 0.8731 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11849.159 | 0.9853 | 0.9763 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11849.159 | 0.9575 | 0.9316 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11849.159 | 0.9458 | 0.9126 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11849.159 | 0.7199 | 0.5370 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11849.159 | 0.3271 | -0.1830 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11849.159 | 0.2157 | -0.4146 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11849.159 | 0.0983 | -0.6881 | 1.2484 | |
| HCC1954 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11055.152 | 1.0274 | 1.0327 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11055.152 | 1.0712 | 1.0844 | 1.6647 |