Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10518.14 | 0.9694 | 0.9491 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10518.14 | 0.9974 | 0.9956 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10518.14 | 0.9753 | 0.9588 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10518.14 | 1.0505 | 1.0835 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10518.14 | 1.0289 | 1.0478 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10518.14 | 0.3864 | -0.0914 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10518.14 | 0.0381 | -0.8671 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10518.14 | 0.0375 | -0.8690 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10753.152 | 0.9655 | 0.9494 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10753.152 | 0.9253 | 0.8898 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10753.152 | 0.9286 | 0.8947 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10753.152 | 1.0191 | 1.0278 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10753.152 | 0.9579 | 0.9381 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10753.152 | 0.9648 | 0.9483 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10753.152 | 0.2928 | -0.1847 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10753.152 | 0.0519 | -0.7697 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10753.152 | 0.0310 | -0.8418 | 1.3690 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12000.159 | 0.9222 | 0.8396 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12000.159 | 0.9320 | 0.8598 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12000.159 | 0.9841 | 0.9672 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12000.159 | 0.9248 | 0.8450 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12000.159 | 0.8591 | 0.7100 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12000.159 | 0.4699 | -0.0824 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12000.159 | 0.2998 | -0.4227 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12000.159 | 0.1547 | -0.7082 | 0.9695 |