Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.533 | uM | 10753.153 | 0.9136 | 0.8739 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 2.67 | uM | 10753.153 | 0.6759 | 0.5083 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 13.3 | uM | 10753.153 | 0.4010 | 0.0354 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 66.7 | uM | 10753.153 | 0.0054 | -0.9537 | 1.3879 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12000.165 | 1.0463 | 1.1339 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12000.165 | 0.9728 | 0.9225 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12000.165 | 0.9937 | 0.9821 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12000.165 | 0.9525 | 0.8652 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.107 | uM | 12000.165 | 0.9898 | 0.9710 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.533 | uM | 12000.165 | 0.9139 | 0.7579 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 2.67 | uM | 12000.165 | 0.8306 | 0.5328 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 13.3 | uM | 12000.165 | 0.5611 | -0.1263 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 66.7 | uM | 12000.165 | 0.0067 | -0.9985 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12084.158 | 0.9175 | 0.8716 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12084.158 | 0.9960 | 0.9938 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12084.158 | 0.9059 | 0.8534 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12084.158 | 1.0075 | 1.0116 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.107 | uM | 12084.158 | 0.9833 | 0.9742 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.533 | uM | 12084.158 | 0.9215 | 0.8779 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 2.67 | uM | 12084.158 | 0.8725 | 0.8004 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 13.3 | uM | 12084.158 | 0.5297 | 0.2256 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 66.7 | uM | 12084.158 | 0.0017 | -0.9851 | 1.2976 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12001.165 | 1.0111 | 1.0414 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12001.165 | 0.9909 | 0.9663 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12001.165 | 0.9300 | 0.7476 | 0.5382 |