Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 12070.158 | 0.3695 | -0.1744 | 1.1252 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12070.158 | 0.0394 | -0.8870 | 1.1252 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12112.158 | 0.8959 | 0.8842 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12112.158 | 0.9048 | 0.8944 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12112.158 | 0.9314 | 0.9244 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12112.158 | 0.8708 | 0.8553 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.107 | uM | 12112.158 | 0.9239 | 0.9159 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.533 | uM | 12112.158 | 0.8425 | 0.8225 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 2.67 | uM | 12112.158 | 0.9166 | 0.9077 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 13.3 | uM | 12112.158 | 0.6577 | 0.5933 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 66.7 | uM | 12112.158 | 0.0104 | -0.8320 | 1.8430 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10518.141 | 0.9024 | 0.8494 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10518.141 | 1.0194 | 1.0295 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.00427 | uM | 10518.141 | 0.9274 | 0.8884 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.0213 | uM | 10518.141 | 0.9595 | 0.9380 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.107 | uM | 10518.141 | 1.0190 | 1.0289 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.533 | uM | 10518.141 | 0.9072 | 0.8569 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 2.67 | uM | 10518.141 | 0.7687 | 0.6367 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 13.3 | uM | 10518.141 | 0.3942 | -0.0162 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 66.7 | uM | 10518.141 | 0.0046 | -0.9668 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10753.153 | 0.9259 | 0.8920 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10753.153 | 0.9831 | 0.9756 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.00427 | uM | 10753.153 | 0.9601 | 0.9422 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.0213 | uM | 10753.153 | 1.0400 | 1.0573 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.107 | uM | 10753.153 | 1.0340 | 1.0488 | 1.3879 |