Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 5899.067 | 0.8647 | 0.7267 | 0.9897 | |
| 600MPE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 5899.067 | 0.4107 | -0.1863 | 0.9897 | |
| 600MPE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 5899.067 | 0.0054 | -0.9898 | 0.9897 | |
| 600MPE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 5899.067 | 0.0003 | -0.9995 | 0.9897 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 5900.067 | 1.0072 | 1.0059 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 5900.067 | 1.0161 | 1.0132 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 5900.067 | 1.0045 | 1.0037 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 5900.067 | 1.0383 | 1.0312 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 5900.067 | 1.0693 | 1.0559 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 5900.067 | 0.8341 | 0.8562 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 5900.067 | 0.3847 | 0.3504 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 5900.067 | 0.0089 | -0.7132 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 5900.067 | 0.0011 | -0.8780 | 2.4324 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 5901.067 | 0.9155 | 0.9081 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 5901.067 | 0.9803 | 0.9789 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 5901.067 | 0.9920 | 0.9915 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 5901.067 | 1.0366 | 1.0387 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 5901.067 | 1.0306 | 1.0324 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 5901.067 | 0.8186 | 0.7976 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 5901.067 | 0.4376 | 0.2875 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 5901.067 | 0.0090 | -0.8378 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 5901.067 | 0.0009 | -0.9518 | 1.8762 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 5902.067 | 0.9329 | 0.8852 | 1.1750 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 5902.067 | 1.0459 | 1.0778 | 1.1750 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 5902.067 | 1.0101 | 1.0172 | 1.1750 |