Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Selumetinib | MEK | MAPK | 10 | uM | 12098.155 | 0.9626 | 0.9288 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 12098.155 | 0.9286 | 0.8639 | 1.0503 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.000128 | uM | 11058.155 | 0.9493 | 0.9504 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.00064 | uM | 11058.155 | 1.0304 | 1.0291 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.0032 | uM | 11058.155 | 0.8586 | 0.8580 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.016 | uM | 11058.155 | 0.8152 | 0.8121 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.08 | uM | 11058.155 | 0.5514 | 0.5002 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 0.4 | uM | 11058.155 | 0.4220 | 0.3185 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 2 | uM | 11058.155 | 0.2778 | 0.0774 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 10 | uM | 11058.155 | 0.2209 | -0.0354 | 2.0706 | |
| SUM229PE | TNBC | - | Selumetinib | MEK | MAPK | 50 | uM | 11058.155 | 0.1279 | -0.2593 | 2.0706 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10695.146 | 1.0583 | 1.0816 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10695.146 | 0.9909 | 0.9872 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10695.146 | 1.0194 | 1.0273 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10695.146 | 1.0421 | 1.0590 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10695.146 | 1.0709 | 1.0990 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10695.146 | 1.0132 | 1.0186 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10695.146 | 0.9171 | 0.8816 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10695.146 | 0.6887 | 0.5375 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10695.146 | 0.5537 | 0.3182 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 11852.155 | 1.0139 | 1.0182 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 11852.155 | 0.9683 | 0.9581 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 11852.155 | 1.0019 | 1.0024 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 11852.155 | 0.9620 | 0.9496 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 11852.155 | 1.0337 | 1.0441 | 1.5196 |