Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 11852.155 | 0.9767 | 0.9693 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 11852.155 | 0.8393 | 0.7822 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 11852.155 | 0.6794 | 0.5508 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 11852.155 | 0.5817 | 0.4002 | 1.5196 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10939.155 | 0.9637 | 0.9518 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10939.155 | 0.9573 | 0.9432 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10939.155 | 0.9819 | 0.9760 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10939.155 | 1.0158 | 1.0208 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10939.155 | 0.9838 | 0.9785 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10939.155 | 0.9429 | 0.9239 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10939.155 | 0.9410 | 0.9213 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10939.155 | 1.0215 | 1.0283 | 1.5150 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10939.155 | 0.9665 | 0.9555 | 1.5150 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.000128 | uM | 12608.155 | 0.9507 | 0.9145 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.00064 | uM | 12608.155 | 0.9528 | 0.9180 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.0032 | uM | 12608.155 | 0.9940 | 0.9896 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.016 | uM | 12608.155 | 0.9857 | 0.9752 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.08 | uM | 12608.155 | 0.9945 | 0.9905 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.4 | uM | 12608.155 | 1.0523 | 1.0903 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 2 | uM | 12608.155 | 1.0042 | 1.0073 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 10 | uM | 12608.155 | 1.0432 | 1.0745 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 50 | uM | 12608.155 | 1.0641 | 1.1105 | 1.1556 | |
| UACC-812 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10754.146 | 1.0270 | 1.0431 | 1.2483 | |
| UACC-812 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10754.146 | 1.0000 | 1.0000 | 1.2483 | |
| UACC-812 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10754.146 | 1.0635 | 1.1012 | 1.2483 |