Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
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BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 12056.158 | 0.9221 | 0.8432 | 0.9929 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 12056.158 | 0.7941 | 0.5855 | 0.9929 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 12056.158 | 0.5642 | 0.1238 | 0.9929 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 12056.158 | 0.2428 | -0.5193 | 0.9929 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12056.158 | 0.0710 | -0.8607 | 0.9929 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12178.158 | 0.9947 | 0.9856 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12178.158 | 0.9540 | 0.8764 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12178.158 | 0.9479 | 0.8601 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12178.158 | 0.9320 | 0.8180 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 12178.158 | 0.9985 | 0.9960 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 12178.158 | 0.8986 | 0.7302 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 12178.158 | 0.7375 | 0.3239 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 12178.158 | 0.2998 | -0.6091 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12178.158 | 0.1179 | -0.8896 | 0.7379 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12291.165 | 0.8639 | 0.5404 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12291.165 | 0.8575 | 0.5199 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12291.165 | 0.9965 | 0.9875 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12291.165 | 0.8544 | 0.5101 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 12291.165 | 0.8529 | 0.5055 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 12291.165 | 0.8014 | 0.3471 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 12291.165 | 0.5127 | -0.3932 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 12291.165 | 0.2200 | -0.8660 | 0.5602 | |
BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12291.165 | 0.0208 | -0.9980 | 0.5602 | |
BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10696.153 | 0.9736 | 0.9047 | 0.5484 | |
BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10696.153 | 0.9653 | 0.8754 | 0.5484 |