Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7511.067 | 1.0104 | 1.0184 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7511.067 | 1.1021 | 1.1805 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7511.067 | 1.0969 | 1.1714 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7511.067 | 1.0847 | 1.1500 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7511.067 | 1.0499 | 1.0885 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7511.067 | 1.1136 | 1.2008 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7512.067 | 1.0042 | 1.0095 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7512.067 | 1.0390 | 1.0895 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7512.067 | 0.9864 | 0.9690 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7512.067 | 1.0723 | 1.1664 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7512.067 | 1.0216 | 1.0495 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7512.067 | 1.0202 | 1.0463 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7512.067 | 1.0198 | 1.0453 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7512.067 | 1.0410 | 1.0942 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7512.067 | 1.0116 | 1.0267 | 0.8735 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7517.067 | 1.0617 | 1.0889 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7517.067 | 1.0542 | 1.0782 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7517.067 | 1.0294 | 1.0425 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7517.067 | 1.0457 | 1.0659 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7517.067 | 1.0187 | 1.0271 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7517.067 | 1.0729 | 1.1048 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7517.067 | 0.7897 | 0.6850 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7517.067 | 0.9375 | 0.9085 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7517.067 | 0.9467 | 0.9220 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7518.067 | 0.2680 | -0.6409 | 0.7666 |