Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7467.067 | 0.9928 | 0.9892 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7467.067 | 0.9389 | 0.9071 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7467.067 | 0.8041 | 0.6966 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 7467.067 | 0.6982 | 0.5251 | 1.3252 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7468.067 | 1.0045 | 1.0065 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7468.067 | 1.0448 | 1.0642 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7468.067 | 0.9876 | 0.9820 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7468.067 | 0.9902 | 0.9858 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7468.067 | 1.0207 | 1.0299 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7468.067 | 0.9920 | 0.9885 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7468.067 | 1.0391 | 1.0561 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7468.067 | 0.8458 | 0.7721 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7468.067 | 0.9418 | 0.9153 | 1.3847 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7469.067 | 0.9661 | 0.9669 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7469.067 | 0.9783 | 0.9788 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7469.067 | 0.9855 | 0.9859 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7469.067 | 0.9386 | 0.9395 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7469.067 | 0.9633 | 0.9640 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7469.067 | 0.9658 | 0.9666 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7469.067 | 0.9172 | 0.9180 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7469.067 | 0.3732 | 0.2405 | 2.0639 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7469.067 | 0.5245 | 0.4629 | 2.0639 | |
| HCC70 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7470.067 | 0.9696 | 0.9435 | 1.0774 | |
| HCC70 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7470.067 | 0.9366 | 0.8821 | 1.0774 | |
| HCC70 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7470.067 | 1.0767 | 1.1420 | 1.0774 |