Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7463.067 | 0.8265 | 0.5042 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7463.067 | 0.7525 | 0.3072 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7464.067 | 1.0359 | 1.0988 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7464.067 | 1.0327 | 1.0901 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7464.067 | 1.0139 | 1.0382 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7464.067 | 1.0557 | 1.1540 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7464.067 | 1.0386 | 1.1065 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7464.067 | 0.9999 | 0.9998 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7464.067 | 0.9922 | 0.9786 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7464.067 | 0.5254 | -0.1709 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7464.067 | 0.4561 | -0.3169 | 0.7308 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7466.067 | 1.0241 | 1.0509 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7466.067 | 1.0094 | 1.0200 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7466.067 | 1.0258 | 1.0546 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7466.067 | 1.0019 | 1.0041 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7466.067 | 1.0338 | 1.0715 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7466.067 | 1.0204 | 1.0431 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7466.067 | 1.0216 | 1.0456 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7466.067 | 0.9756 | 0.9484 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 7466.067 | 0.9780 | 0.9536 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7467.067 | 0.9952 | 0.9928 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7467.067 | 0.9667 | 0.9496 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7467.067 | 0.9752 | 0.9625 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7467.067 | 0.9510 | 0.9256 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7467.067 | 0.9703 | 0.9551 | 1.3252 |