Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5909.067 | 1.1115 | 1.0751 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5909.067 | 1.0783 | 1.0533 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5909.067 | 1.0476 | 1.0327 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5909.067 | 1.0848 | 1.0575 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5909.067 | 1.0731 | 1.0498 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5909.067 | 1.0673 | 1.0459 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5909.067 | 1.0906 | 1.0614 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5909.067 | 1.0093 | 1.0065 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 5909.067 | 0.9423 | 0.9590 | 2.8695 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5910.067 | 1.1650 | 1.0958 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5910.067 | 1.1368 | 1.0802 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5910.067 | 1.0630 | 1.0378 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5910.067 | 1.1007 | 1.0597 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5910.067 | 1.1514 | 1.0883 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5910.067 | 1.2071 | 1.1188 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5910.067 | 0.9171 | 0.9477 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5910.067 | 0.7578 | 0.8370 | 3.2630 | |
| BT-549 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 5910.067 | 0.7891 | 0.8600 | 3.2630 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5911.067 | 1.0134 | 1.0268 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5911.067 | 1.0161 | 1.0320 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5911.067 | 1.0128 | 1.0255 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5911.067 | 1.0016 | 1.0031 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5911.067 | 0.9768 | 0.9537 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5911.067 | 1.0195 | 1.0389 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5911.067 | 0.9619 | 0.9241 | 1.0037 |