Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 10817.155 | 0.3437 | 0.0278 | 1.6045 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 10817.155 | 0.2942 | -0.0670 | 1.6045 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 12365.155 | 0.9486 | 0.9506 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 12365.155 | 0.9419 | 0.9441 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 12365.155 | 0.9225 | 0.9250 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 12365.155 | 0.8164 | 0.8167 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 12365.155 | 0.6673 | 0.6513 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 12365.155 | 0.5824 | 0.5483 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 12365.155 | 0.3957 | 0.2892 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 12365.155 | 0.2983 | 0.1277 | 2.1113 | |
| MCF12A | NM | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 12365.155 | 0.2993 | 0.1295 | 2.1113 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10997.155 | 1.0338 | 1.0512 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10997.155 | 1.0147 | 1.0223 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10997.155 | 1.0506 | 1.0765 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10997.155 | 1.0567 | 1.0856 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10997.155 | 0.9785 | 0.9673 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10997.155 | 1.0310 | 1.0470 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10997.155 | 0.9664 | 0.9487 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10997.155 | 1.0161 | 1.0244 | 1.3159 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10997.155 | 0.9688 | 0.9524 | 1.3159 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10998.155 | 0.9801 | 0.9572 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10998.155 | 0.9423 | 0.8762 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10998.155 | 0.9517 | 0.8963 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10998.155 | 0.9742 | 0.9446 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10998.155 | 0.8552 | 0.6905 | 0.9302 |