Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7458.067 | 0.9584 | 0.8568 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7458.067 | 0.9788 | 0.9264 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7458.067 | 1.0445 | 1.1585 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7458.067 | 0.9883 | 0.9593 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7458.067 | 1.0296 | 1.1049 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7458.067 | 1.0523 | 1.1867 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7458.067 | 0.9479 | 0.8211 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7458.067 | 0.9330 | 0.7713 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7458.067 | 0.7713 | 0.2696 | 0.5714 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7462.067 | 1.0311 | 1.1299 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7462.067 | 0.9900 | 0.9592 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7462.067 | 1.0239 | 1.0994 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7462.067 | 1.0207 | 1.0858 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7462.067 | 1.0219 | 1.0911 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7462.067 | 1.0287 | 1.1195 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7462.067 | 1.0115 | 1.0476 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7462.067 | 0.9837 | 0.9338 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7462.067 | 1.0176 | 1.0730 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7463.067 | 0.9854 | 0.9566 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7463.067 | 0.9512 | 0.8559 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7463.067 | 0.9918 | 0.9755 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7463.067 | 0.9898 | 0.9695 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7463.067 | 0.9711 | 0.9143 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7463.067 | 1.0090 | 1.0271 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7463.067 | 0.9385 | 0.8189 | 0.6688 |