Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7507.067 | 1.0079 | 1.0160 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7507.067 | 1.0033 | 1.0066 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7507.067 | 0.9364 | 0.8713 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7507.067 | 0.7547 | 0.5042 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7508.067 | 0.9732 | 0.9294 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7508.067 | 0.9789 | 0.9444 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7508.067 | 0.9537 | 0.8785 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7508.067 | 0.9844 | 0.9589 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7508.067 | 0.9876 | 0.9672 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7508.067 | 0.9558 | 0.8839 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7508.067 | 1.0003 | 1.0008 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7508.067 | 0.9678 | 0.9152 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7508.067 | 0.9839 | 0.9574 | 0.7560 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7510.067 | 0.9982 | 0.9956 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7510.067 | 1.0219 | 1.0526 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7510.067 | 0.9903 | 0.9768 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7510.067 | 1.0513 | 1.1235 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7510.067 | 0.9436 | 0.8656 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7510.067 | 1.0354 | 1.0852 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7510.067 | 1.0425 | 1.1024 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7510.067 | 1.0814 | 1.1967 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7510.067 | 0.7971 | 0.5243 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7511.067 | 1.0735 | 1.1302 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7511.067 | 1.0778 | 1.1377 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7511.067 | 1.0401 | 1.0712 | 1.1247 |