Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7518.067 | 1.0150 | 1.0392 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7518.067 | 1.3425 | 1.9369 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7518.067 | 1.3878 | 2.0668 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7518.067 | 0.3703 | -0.4527 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7518.067 | 1.3042 | 1.8281 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7518.067 | 1.0479 | 1.1260 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7518.067 | 0.9517 | 0.8749 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7518.067 | 0.9989 | 0.9970 | 0.7666 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7523.067 | 0.9550 | 0.8931 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7523.067 | 0.9213 | 0.8137 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7523.067 | 0.9191 | 0.8085 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7523.067 | 1.0002 | 1.0006 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7523.067 | 0.9412 | 0.8606 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7523.067 | 0.9619 | 0.9095 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7523.067 | 0.9966 | 0.9918 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7523.067 | 0.9808 | 0.9544 | 0.8380 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 167 | uM | 7523.067 | 0.9299 | 0.8338 | 0.8380 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7526.067 | 0.9821 | 0.9803 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7526.067 | 1.0002 | 1.0002 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7526.067 | 0.9678 | 0.9644 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7526.067 | 0.9936 | 0.9929 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7526.067 | 0.9661 | 0.9624 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7526.067 | 1.0496 | 1.0539 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7526.067 | 0.9602 | 0.9559 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7526.067 | 0.5127 | 0.3852 | 1.8189 |