Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7490.067 | 1.0085 | 1.0064 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7490.067 | 1.0291 | 1.0218 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7490.067 | 0.9958 | 0.9968 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7490.067 | 0.9861 | 0.9894 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7490.067 | 0.9305 | 0.9463 | 2.6472 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7492.067 | 0.9140 | 0.8777 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7492.067 | 0.9551 | 0.9365 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7492.067 | 0.9338 | 0.9061 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7492.067 | 0.9652 | 0.9508 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7492.067 | 0.9642 | 0.9495 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7492.067 | 1.0042 | 1.0059 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7492.067 | 0.8801 | 0.8285 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7492.067 | 0.3921 | 0.0365 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7492.067 | 0.2759 | -0.1902 | 1.4243 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7493.067 | 0.9173 | 0.8778 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7493.067 | 0.9237 | 0.8873 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7493.067 | 0.9516 | 0.9288 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7493.067 | 0.9338 | 0.9023 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7493.067 | 0.9870 | 0.9810 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7493.067 | 0.9300 | 0.8966 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7493.067 | 0.9582 | 0.9386 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7493.067 | 0.9472 | 0.9222 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7493.067 | 0.9486 | 0.9243 | 1.3684 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7494.067 | 0.9765 | 0.9458 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7494.067 | 0.9594 | 0.9065 | 0.8649 |