Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7485.067 | 0.9182 | 0.9551 | 3.7597 | |
| MCF 10A | NM | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7485.067 | 0.8153 | 0.8943 | 3.7597 | |
| MCF 10A | NM | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7485.067 | 0.8332 | 0.9052 | 3.7597 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7487.067 | 1.0086 | 1.0127 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7487.067 | 0.9671 | 0.9512 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7487.067 | 1.0369 | 1.0543 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7487.067 | 1.0015 | 1.0022 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7487.067 | 0.9671 | 0.9512 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7487.067 | 0.9380 | 0.9076 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7487.067 | 0.9592 | 0.9393 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7487.067 | 0.3243 | -0.1303 | 1.3523 | |
| MCF 10F | NM | - | Purvalanol A | CDK1 | CDK | 167 | uM | 7487.067 | 0.2163 | -0.3555 | 1.3523 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7489.067 | 1.0476 | 1.0536 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7489.067 | 0.9961 | 0.9956 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7489.067 | 1.0823 | 1.0919 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7489.067 | 1.0365 | 1.0411 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7489.067 | 1.1104 | 1.1226 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7489.067 | 1.0333 | 1.0376 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7489.067 | 1.1089 | 1.1209 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7489.067 | 0.4506 | 0.2716 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7489.067 | 0.2934 | -0.0035 | 1.7603 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7490.067 | 0.9820 | 0.9863 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7490.067 | 0.9268 | 0.9434 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7490.067 | 0.9867 | 0.9899 | 2.6472 | |
| MCF12A | NM | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7490.067 | 0.9918 | 0.9938 | 2.6472 |