Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7494.067 | 0.9414 | 0.8651 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7494.067 | 0.9423 | 0.8673 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7494.067 | 0.9170 | 0.8094 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7494.067 | 0.9896 | 0.9760 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7494.067 | 0.9826 | 0.9597 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7494.067 | 0.9502 | 0.8853 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7494.067 | 0.6891 | 0.3002 | 0.8649 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7495.067 | 1.0468 | 1.0828 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7495.067 | 0.9435 | 0.8994 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7495.067 | 1.0070 | 1.0123 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7495.067 | 0.9812 | 0.9665 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7495.067 | 1.0278 | 1.0493 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7495.067 | 1.0177 | 1.0314 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7495.067 | 0.7430 | 0.5367 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7495.067 | 0.8337 | 0.7020 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7495.067 | 0.7175 | 0.4899 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7496.067 | 1.0371 | 1.0655 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7496.067 | 0.9920 | 0.9859 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7496.067 | 1.0006 | 1.0010 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7496.067 | 1.0092 | 1.0163 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7496.067 | 0.9491 | 0.9097 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7496.067 | 0.9970 | 0.9948 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7496.067 | 0.9447 | 0.9018 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7496.067 | 0.9593 | 0.9278 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 167 | uM | 7496.067 | 0.9464 | 0.9048 | 1.1301 |