Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7532.095 | 1.0332 | 1.0901 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7532.095 | 1.0683 | 1.1863 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7532.095 | 1.0301 | 1.0817 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7532.095 | 1.0860 | 1.2354 | 0.7413 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7533.095 | 0.9565 | 0.9117 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7533.095 | 1.0501 | 1.1018 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7533.095 | 1.0021 | 1.0043 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7533.095 | 0.9380 | 0.8741 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7533.095 | 1.0344 | 1.0700 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7533.095 | 0.9364 | 0.8708 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7533.095 | 0.9626 | 0.9240 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7533.095 | 0.8845 | 0.7658 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7533.095 | 1.0330 | 1.0669 | 0.9850 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7534.095 | 1.0073 | 1.0181 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7534.095 | 1.1001 | 1.2516 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7534.095 | 0.9894 | 0.9737 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7534.095 | 1.1012 | 1.2543 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7534.095 | 1.0281 | 1.0699 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7534.095 | 0.9851 | 0.9631 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7534.095 | 0.9992 | 0.9981 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7534.095 | 0.9398 | 0.8515 | 0.8052 | |
| SUM225CWN | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7534.095 | 1.0055 | 1.0136 | 0.8052 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7535.095 | 0.9212 | 0.8080 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7535.095 | 0.9068 | 0.7732 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7535.095 | 0.8048 | 0.5311 | 0.8131 |