Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7490.095 | 0.4142 | 0.4471 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7490.095 | 0.4210 | 0.4558 | 2.7242 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7492.095 | 1.9139 | 2.7810 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7492.095 | 0.5662 | 0.1446 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7492.095 | 0.9285 | 0.8596 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7492.095 | 1.2032 | 1.3980 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7492.095 | 1.0171 | 1.0336 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7492.095 | 0.7718 | 0.5513 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7492.095 | 0.7325 | 0.4737 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7492.095 | 1.1118 | 1.2191 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7492.095 | 0.8948 | 0.7935 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7493.095 | 0.9898 | 0.9798 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7493.095 | 1.0133 | 1.0264 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7493.095 | 0.9778 | 0.9560 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7493.095 | 0.8773 | 0.7568 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7493.095 | 0.7969 | 0.5971 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7493.095 | 0.7430 | 0.4900 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7493.095 | 0.7652 | 0.5341 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7493.095 | 0.8002 | 0.6037 | 1.0092 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7493.095 | 0.8788 | 0.7596 | 1.0092 | |
| MDA-MB-134-VI | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7494.094 | 0.9300 | 0.8571 | 0.9794 | |
| MDA-MB-134-VI | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7494.094 | 0.9267 | 0.8505 | 0.9794 | |
| MDA-MB-134-VI | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7494.094 | 0.9814 | 0.9620 | 0.9794 | |
| MDA-MB-134-VI | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7494.094 | 0.9181 | 0.8329 | 0.9794 | |
| MDA-MB-134-VI | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7494.094 | 0.8766 | 0.7484 | 0.9794 |