Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7454.095 | 0.8911 | 0.8068 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7454.095 | 0.9695 | 0.9461 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7454.095 | 1.0250 | 1.0441 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7454.095 | 0.9753 | 0.9563 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7454.095 | 0.9370 | 0.8886 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7454.095 | 0.8597 | 0.7506 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7454.095 | 0.8446 | 0.7236 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7454.095 | 0.9333 | 0.8820 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7454.095 | 0.8411 | 0.7171 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7455.095 | 0.9468 | 0.9416 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7455.095 | 0.9363 | 0.9300 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7455.095 | 0.8154 | 0.7907 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7455.095 | 0.7453 | 0.7056 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7455.095 | 0.7472 | 0.7080 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7455.095 | 0.8086 | 0.7826 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7455.095 | 0.7758 | 0.7430 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7455.095 | 0.0358 | -0.6708 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7455.095 | 1.0088 | 1.0095 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7456.095 | 0.9887 | 0.9884 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7456.095 | 0.9494 | 0.9477 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7456.095 | 0.6685 | 0.6284 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7456.095 | 0.4806 | 0.3759 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7456.095 | 0.4518 | 0.3331 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7456.095 | 0.4332 | 0.3048 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7456.095 | 0.4567 | 0.3406 | 1.9589 |