Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7456.095 | 0.4444 | 0.3219 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7456.095 | 0.5466 | 0.4693 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7457.094 | 0.7485 | 0.7096 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7457.094 | 0.8903 | 0.8780 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7457.094 | 0.7929 | 0.7638 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7457.094 | 0.6806 | 0.6237 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7457.094 | 0.7945 | 0.7657 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7457.094 | 0.7453 | 0.7055 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7457.094 | 0.7778 | 0.7454 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7457.094 | 0.8298 | 0.8077 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7457.094 | 0.8645 | 0.8483 | 1.8462 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7458.095 | 0.9260 | 0.6295 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7458.095 | 0.8674 | 0.3689 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7458.095 | 0.7394 | -0.1057 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7458.095 | 0.7535 | -0.0595 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7458.095 | 0.7033 | -0.2172 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7458.095 | 0.7082 | -0.2028 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7458.095 | 0.6658 | -0.3238 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7458.095 | 0.6702 | -0.3116 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7458.095 | 0.7980 | 0.0962 | 0.3752 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7462.095 | 0.9566 | 0.7817 | 0.3840 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7462.095 | 1.0269 | 1.1432 | 0.3840 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7462.095 | 0.9814 | 0.9048 | 0.3840 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7462.095 | 1.0290 | 1.1544 | 0.3840 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7462.095 | 1.0085 | 1.0445 | 0.3840 |