Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7485.095 | 1.0377 | 1.0203 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7485.095 | 1.0051 | 1.0028 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7485.095 | 0.8227 | 0.8962 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7485.095 | 0.6023 | 0.7415 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7485.095 | 0.4783 | 0.6353 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7485.095 | 0.4196 | 0.5778 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7485.095 | 0.4124 | 0.5703 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7485.095 | 0.4603 | 0.6182 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7485.095 | 0.6780 | 0.7987 | 3.6625 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7486.095 | 1.0459 | 1.0974 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7486.095 | 0.9594 | 0.9143 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7486.095 | 0.8206 | 0.6222 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7486.095 | 0.7843 | 0.5465 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7486.095 | 0.8024 | 0.5843 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7486.095 | 0.7902 | 0.5588 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7486.095 | 0.8557 | 0.6959 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7486.095 | 0.8173 | 0.6155 | 0.9448 | |
| MCF 10F | NM | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7486.095 | 0.7796 | 0.5367 | 0.9448 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7490.095 | 0.9693 | 0.9772 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7490.095 | 0.9479 | 0.9611 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7490.095 | 0.5834 | 0.6410 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7490.095 | 0.4489 | 0.4906 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7490.095 | 0.4361 | 0.4747 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7490.095 | 0.4328 | 0.4707 | 2.7242 | |
| MCF12A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7490.095 | 0.4144 | 0.4475 | 2.7242 |