Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 10381.095 | 0.9388 | 0.9036 | 1.2787 | |
| SUM1315MO2 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 10381.095 | 1.0034 | 1.0053 | 1.2787 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7530.095 | 1.0186 | 1.0163 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7530.095 | 1.0229 | 1.0201 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7530.095 | 0.9566 | 0.9612 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7530.095 | 0.9902 | 0.9913 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7530.095 | 0.8981 | 0.9074 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7530.095 | 0.8719 | 0.8827 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7530.095 | 0.9037 | 0.9126 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7530.095 | 0.8726 | 0.8833 | 2.2670 | |
| SUM149PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7530.095 | 0.8055 | 0.8180 | 2.2670 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7531.095 | 0.9491 | 0.9706 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7531.095 | 0.9945 | 0.9969 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7531.095 | 0.8906 | 0.9354 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7531.095 | 0.9265 | 0.9572 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7531.095 | 0.8894 | 0.9347 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7531.095 | 0.8606 | 0.9167 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7531.095 | 0.8933 | 0.9371 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7531.095 | 0.9546 | 0.9739 | 3.5302 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7531.095 | 0.9174 | 0.9518 | 3.5302 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7532.095 | 0.9858 | 0.9617 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7532.095 | 1.0327 | 1.0887 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7532.095 | 1.0343 | 1.0931 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7532.095 | 1.0512 | 1.1393 | 0.7413 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7532.095 | 1.0743 | 1.2029 | 0.7413 |