Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7535.095 | 0.7385 | 0.3776 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7535.095 | 0.7833 | 0.4811 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7535.095 | 0.7309 | 0.3601 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7535.095 | 0.8016 | 0.5237 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7535.095 | 0.7792 | 0.4716 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7535.095 | 0.6895 | 0.2660 | 0.8131 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7537.095 | 0.9884 | 0.9883 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7537.095 | 1.0083 | 1.0084 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7537.095 | 0.8167 | 0.8062 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7537.095 | 0.7502 | 0.7306 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7537.095 | 0.7674 | 0.7505 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7537.095 | 0.7406 | 0.7194 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7537.095 | 0.7421 | 0.7212 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7537.095 | 0.7124 | 0.6861 | 1.9867 | |
| SUM229PE | TNBC | - | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7537.095 | 0.6407 | 0.5985 | 1.9867 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7539.095 | 0.9076 | 0.8368 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7539.095 | 0.8735 | 0.7761 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7539.095 | 0.9237 | 0.8654 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7539.095 | 0.9292 | 0.8751 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7539.095 | 0.9232 | 0.8645 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7539.095 | 0.8425 | 0.7207 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7539.095 | 0.6860 | 0.4367 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7539.095 | 0.9084 | 0.8383 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7539.095 | 0.6353 | 0.3429 | 1.1392 | |
| SUM52PE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7541.095 | 0.9926 | 0.9898 | 1.4542 |