Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5910.095 | 0.9100 | 0.9432 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5910.095 | 0.9782 | 0.9866 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5910.095 | 0.9132 | 0.9453 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5910.095 | 0.9613 | 0.9760 | 3.2727 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5911.094 | 0.9567 | 0.9146 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5911.094 | 0.9422 | 0.8861 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5911.094 | 0.7485 | 0.5033 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5911.094 | 0.7174 | 0.4416 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5911.094 | 0.7287 | 0.4640 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5911.094 | 0.7178 | 0.4425 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5911.094 | 0.7156 | 0.4381 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5911.094 | 0.7339 | 0.4743 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5911.094 | 0.8453 | 0.6947 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5912.095 | 0.9508 | 0.9014 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5912.095 | 0.9500 | 0.8999 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5912.095 | 0.9663 | 0.9325 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5912.095 | 0.8825 | 0.7647 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5912.095 | 0.8695 | 0.7385 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5912.095 | 0.9019 | 0.8035 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5912.095 | 0.8156 | 0.6306 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5912.095 | 0.9010 | 0.8017 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5912.095 | 0.8893 | 0.7782 | 0.9981 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7430.095 | 0.9215 | 0.9174 | 1.9390 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7430.095 | 0.9984 | 0.9983 | 1.9390 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7430.095 | 0.9165 | 0.9121 | 1.9390 |