Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5906.095 | 1.0043 | 1.0129 | 0.6731 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5906.095 | 1.1144 | 1.3493 | 0.6731 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5908.095 | 0.9654 | 0.8642 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5908.095 | 0.9332 | 0.7422 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5908.095 | 0.8830 | 0.5604 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5908.095 | 0.7275 | 0.0601 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5908.095 | 0.8416 | 0.4178 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5908.095 | 0.8644 | 0.4954 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5908.095 | 0.9053 | 0.6399 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5908.095 | 0.8652 | 0.4981 | 0.5012 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5908.095 | 0.9443 | 0.7839 | 0.5012 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5909.095 | 0.9890 | 0.9920 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5909.095 | 1.1294 | 1.0898 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5909.095 | 1.0423 | 1.0301 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5909.095 | 1.0654 | 1.0463 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5909.095 | 1.0395 | 1.0281 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5909.095 | 0.9452 | 0.9597 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5909.095 | 0.8965 | 0.9227 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5909.095 | 0.8836 | 0.9127 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5909.095 | 0.9622 | 0.9724 | 2.7716 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5910.095 | 1.0527 | 1.0316 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5910.095 | 1.1593 | 1.0924 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5910.095 | 1.0316 | 1.0191 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5910.095 | 0.9853 | 0.9910 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5910.095 | 0.9726 | 0.9831 | 3.2727 |