Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 11939.159 | 0.8448 | 0.8030 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 11939.159 | 0.6238 | 0.4964 | 1.6270 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 5895.093 | 1.0966 | 1.1441 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 5895.093 | 0.9667 | 0.9495 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 5895.093 | 1.0338 | 1.0507 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 5895.093 | 1.0560 | 1.0840 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 5895.093 | 1.0643 | 1.0962 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 5895.093 | 1.0417 | 1.0626 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 5895.093 | 0.9803 | 0.9703 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 5895.093 | 0.7597 | 0.6255 | 1.3259 | |
| 184A1 | NM | Basal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 5895.093 | 0.3592 | -0.0760 | 1.3259 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 5897.093 | 1.0139 | 1.0230 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 5897.093 | 1.0342 | 1.0566 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 5897.093 | 1.0616 | 1.1017 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 5897.093 | 1.0450 | 1.0744 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 5897.093 | 1.0137 | 1.0228 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 5897.093 | 1.0541 | 1.0894 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 5897.093 | 1.0535 | 1.0884 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 5897.093 | 1.0260 | 1.0431 | 1.2047 | |
| 184B5 | NM | Basal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 5897.093 | 0.5425 | 0.2039 | 1.2047 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 5898.093 | 0.9465 | 0.8481 | 0.6963 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 5898.093 | 0.9398 | 0.8295 | 0.6963 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 5898.093 | 0.9455 | 0.8454 | 0.6963 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 5898.093 | 0.9250 | 0.7882 | 0.6963 | |
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 5898.093 | 0.9511 | 0.8611 | 0.6963 |