Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 11660.152 | 0.9278 | 0.8549 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 11660.152 | 0.9189 | 0.8370 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 11660.152 | 0.9351 | 0.8696 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 11660.152 | 0.9418 | 0.8830 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 11660.152 | 0.9881 | 0.9762 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 11660.152 | 0.9404 | 0.8803 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 11660.152 | 0.9704 | 0.9404 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 11660.152 | 0.9073 | 0.8137 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 11660.152 | 0.8286 | 0.6556 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 12003.159 | 0.8270 | 0.7173 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 12003.159 | 0.8670 | 0.7837 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 12003.159 | 0.9847 | 0.9755 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 12003.159 | 0.8276 | 0.7184 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 12003.159 | 0.9032 | 0.8431 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 12003.159 | 0.8234 | 0.7113 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 12003.159 | 0.8664 | 0.7826 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 12003.159 | 0.7565 | 0.5988 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 12003.159 | 0.6445 | 0.4060 | 1.2466 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 11939.159 | 0.9288 | 0.9113 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 11939.159 | 0.9497 | 0.9376 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 11939.159 | 1.0032 | 1.0039 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 11939.159 | 0.9737 | 0.9675 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 11939.159 | 1.0114 | 1.0140 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 11939.159 | 0.9407 | 0.9262 | 1.6270 | |
| ZR75B | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 11939.159 | 0.9749 | 0.9690 | 1.6270 |