Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.267 | uM | 10644.087 | 0.2662 | -0.8032 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 1.33 | uM | 10644.087 | 0.1532 | -0.9252 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 6.67 | uM | 10644.087 | 0.0436 | -0.9917 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 33.3 | uM | 10644.087 | 0.0179 | -0.9983 | 0.5708 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7527.086 | 0.9698 | 0.9637 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7527.086 | 0.9178 | 0.9001 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7527.086 | 0.7355 | 0.6647 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7527.086 | 0.4926 | 0.3102 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7527.086 | 0.3377 | 0.0456 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7527.086 | 0.3190 | 0.0106 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7527.086 | 0.3198 | 0.0122 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7527.086 | 0.2964 | -0.0326 | 1.6742 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7527.086 | 0.3064 | -0.0134 | 1.6742 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10381.087 | 1.0348 | 1.0815 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10381.087 | 0.9612 | 0.9097 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10381.087 | 0.8264 | 0.6008 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10381.087 | 0.7776 | 0.4910 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10381.087 | 0.6489 | 0.2070 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 10381.087 | 0.4722 | -0.1673 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 10381.087 | 0.4196 | -0.2744 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 10381.087 | 0.3907 | -0.3324 | 0.8565 | |
| SUM1315MO2 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 10381.087 | 0.2126 | -0.6720 | 0.8565 | |
| SUM149PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7530.086 | 0.9697 | 0.9723 | 2.2038 | |
| SUM149PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7530.086 | 0.8735 | 0.8810 | 2.2038 | |
| SUM149PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7530.086 | 0.8289 | 0.8368 | 2.2038 |