Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 10469.087 | 0.0462 | -0.7113 | 1.5889 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10469.087 | 0.0113 | -0.8807 | 1.5889 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10470.087 | 1.0206 | 1.1151 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10470.087 | 0.9245 | 0.6119 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10470.087 | 0.8322 | 0.2076 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10470.087 | 0.4718 | -0.7460 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10470.087 | 0.1954 | -0.9774 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10470.087 | 0.1330 | -0.9922 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10470.087 | 0.1072 | -0.9957 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10470.087 | 0.0636 | -0.9990 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10470.087 | 0.0436 | -0.9996 | 0.3641 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7465.087 | 1.0831 | 1.1385 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7465.087 | 0.9458 | 0.9086 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7465.087 | 0.9678 | 0.9459 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7465.087 | 0.8587 | 0.7601 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7465.087 | 0.7075 | 0.4963 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 7465.087 | 0.4796 | 0.0798 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 7465.087 | 0.3284 | -0.2139 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 7465.087 | 0.3198 | -0.2313 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 7465.087 | 0.1774 | -0.5310 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7466.087 | 1.0340 | 1.0746 | 0.9127 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7466.087 | 0.9672 | 0.9283 | 0.9127 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7466.087 | 0.9902 | 0.9784 | 0.9127 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7466.087 | 0.8621 | 0.7000 | 0.9127 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7466.087 | 0.7427 | 0.4437 | 0.9127 |