Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7511.086 | 0.0479 | -0.8262 | 1.2442 | |
| MDA-MB-415 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7511.086 | 0.0082 | -0.9581 | 1.2442 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7515.087 | 0.8459 | 0.7215 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7515.087 | 0.7727 | 0.5874 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7515.087 | 0.7664 | 0.5758 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7515.087 | 0.6624 | 0.3827 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7515.087 | 0.3790 | -0.1615 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7515.087 | 0.1888 | -0.5510 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7515.087 | 0.1136 | -0.7151 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7515.087 | 0.0770 | -0.7989 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7515.087 | 0.0657 | -0.8256 | 1.1161 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7517.086 | 1.0255 | 1.0359 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7517.086 | 0.8529 | 0.7869 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7517.086 | 0.8742 | 0.8184 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7517.086 | 0.6488 | 0.4724 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7517.086 | 0.3719 | -0.0070 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7517.086 | 0.1794 | -0.4073 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7517.086 | 0.0844 | -0.6525 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7517.086 | 0.0652 | -0.7106 | 1.4126 | |
| MDA-MB-453 | TNBC | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7517.086 | 0.0105 | -0.9208 | 1.4126 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10644.087 | 1.0148 | 1.0520 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10644.087 | 0.8747 | 0.5817 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10644.087 | 1.0061 | 1.0213 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10644.087 | 0.7226 | 0.1320 | 0.5708 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10644.087 | 0.5077 | -0.3901 | 0.5708 |