Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7498.086 | 0.9868 | 0.9748 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7498.086 | 0.8845 | 0.7781 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7498.086 | 0.8563 | 0.7237 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 7498.086 | 0.7287 | 0.4767 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 7498.086 | 0.5611 | 0.1497 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 7498.086 | 0.4683 | -0.0333 | 1.0436 | |
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 7498.086 | 0.3348 | -0.2991 | 1.0436 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10642.087 | 0.9853 | 0.9551 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10642.087 | 0.9182 | 0.7547 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10642.087 | 0.9057 | 0.7183 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10642.087 | 0.7782 | 0.3619 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10642.087 | 0.4644 | -0.3828 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10642.087 | 0.2977 | -0.6878 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10642.087 | 0.2681 | -0.7341 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10642.087 | 0.2392 | -0.7767 | 0.6524 | |
| MDA-MB-175-VII | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10642.087 | 0.0537 | -0.9774 | 0.6524 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7506.086 | 1.0672 | 1.1279 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7506.086 | 1.0252 | 1.0481 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7506.086 | 0.9400 | 0.8855 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7506.086 | 0.9817 | 0.9651 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7506.086 | 0.7863 | 0.5906 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7506.086 | 0.3522 | -0.2599 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7506.086 | 0.0533 | -0.8776 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7506.086 | 0.0419 | -0.9027 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7506.086 | 0.0377 | -0.9119 | 1.0496 |