Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10441.087 | 0.7651 | 0.5245 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10441.087 | 0.4287 | -0.1527 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10441.087 | 0.4422 | -0.1255 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10441.087 | 0.4132 | -0.1836 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10441.087 | 0.2640 | -0.4816 | 0.9863 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7449.086 | 1.0101 | 1.0099 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7449.086 | 0.9593 | 0.9599 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7449.086 | 0.9141 | 0.9142 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7449.086 | 0.6874 | 0.6657 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7449.086 | 0.4002 | 0.2795 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 7449.086 | 0.2362 | -0.0108 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 7449.086 | 0.2518 | 0.0207 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 7449.086 | 0.2275 | -0.0287 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 7449.086 | 0.2324 | -0.0186 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10442.087 | 1.0405 | 1.0511 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10442.087 | 1.0851 | 1.1066 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10442.087 | 0.9702 | 0.9619 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10442.087 | 0.7849 | 0.7146 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10442.087 | 0.3988 | 0.1146 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 10442.087 | 0.2660 | -0.1384 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 10442.087 | 0.2818 | -0.1062 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 10442.087 | 0.2466 | -0.1788 | 1.5727 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10442.087 | 0.2403 | -0.1923 | 1.5727 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7451.086 | 1.0032 | 1.0033 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7451.086 | 0.9460 | 0.9437 | 1.9434 |