Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7451.086 | 0.8519 | 0.8416 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7451.086 | 0.7675 | 0.7454 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7451.086 | 0.5572 | 0.4803 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 7451.086 | 0.2703 | 0.0203 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 7451.086 | 0.1555 | -0.2325 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 7451.086 | 0.1198 | -0.3288 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 7451.086 | 0.0572 | -0.5411 | 1.9434 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7453.086 | 1.0417 | 1.0582 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7453.086 | 0.9595 | 0.9427 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7453.086 | 0.9390 | 0.9135 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7453.086 | 0.7840 | 0.6858 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7453.086 | 0.5840 | 0.3708 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 7453.086 | 0.3837 | 0.0206 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 7453.086 | 0.3202 | -0.1011 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 7453.086 | 0.2764 | -0.1895 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 7453.086 | 0.1707 | -0.4222 | 1.4238 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7454.087 | 0.9135 | 0.8566 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7454.087 | 0.7301 | 0.5440 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7454.087 | 0.8483 | 0.7468 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7454.087 | 0.6071 | 0.3267 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7454.087 | 0.1913 | -0.4870 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 7454.087 | 0.0953 | -0.7108 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 7454.087 | 0.0851 | -0.7365 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 7454.087 | 0.0578 | -0.8082 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 7454.087 | 0.0579 | -0.8081 | 1.2157 |