Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12003.147 | 0.9105 | 0.8482 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12003.147 | 0.8892 | 0.8119 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12003.147 | 0.9097 | 0.8469 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12003.147 | 0.9630 | 0.9376 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12003.147 | 0.8340 | 0.7168 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12003.147 | 0.3530 | -0.1672 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 12003.147 | 0.5368 | 0.1849 | 1.1884 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 11939.147 | 1.0266 | 1.0329 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 11939.147 | 0.9552 | 0.9438 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 11939.147 | 1.0272 | 1.0336 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 11939.147 | 0.9966 | 0.9958 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 11939.147 | 1.0113 | 1.0140 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 11939.147 | 1.0739 | 1.0905 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 11939.147 | 0.7986 | 0.7392 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 11939.147 | 0.1918 | -0.2828 | 1.6102 | |
| ZR75B | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 11939.147 | 0.3098 | -0.0340 | 1.6102 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5895.086 | 1.0450 | 1.0699 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 5895.086 | 0.8624 | 0.7816 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 5895.086 | 0.6557 | 0.4384 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 5895.086 | 0.4513 | 0.0743 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 5895.086 | 0.3962 | -0.0297 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 0.267 | uM | 5895.086 | 0.3797 | -0.0613 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 1.33 | uM | 5895.086 | 0.3747 | -0.0709 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 6.67 | uM | 5895.086 | 0.3837 | -0.0535 | 1.2802 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 33.3 | uM | 5895.086 | 0.1681 | -0.5032 | 1.2802 |