Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 12224.152 | 0.9677 | 0.9399 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 12224.152 | 0.9872 | 0.9762 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 12224.152 | 1.0134 | 1.0248 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 12224.152 | 0.9562 | 0.9185 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 12224.152 | 0.9942 | 0.9893 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 12224.152 | 0.9830 | 0.9684 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 12224.152 | 0.9715 | 0.9470 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 12224.152 | 0.9379 | 0.8843 | 1.0761 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 12224.152 | 0.8261 | 0.6747 | 1.0761 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10880.152 | 0.9695 | 0.9592 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10880.152 | 0.9918 | 0.9891 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10880.152 | 0.9785 | 0.9713 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10880.152 | 0.9374 | 0.9157 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10880.152 | 0.9920 | 0.9894 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10880.152 | 0.9289 | 0.9041 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10880.152 | 0.8427 | 0.7846 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10880.152 | 0.6337 | 0.4761 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10880.152 | 0.4777 | 0.2230 | 1.5019 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.000256 | uM | 10581.136 | 1.1030 | 1.2494 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.00128 | uM | 10581.136 | 0.9379 | 0.8521 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.0064 | uM | 10581.136 | 0.9416 | 0.8609 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.032 | uM | 10581.136 | 0.9364 | 0.8485 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.16 | uM | 10581.136 | 1.0525 | 1.1265 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.8 | uM | 10581.136 | 0.9338 | 0.8424 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 4 | uM | 10581.136 | 0.9211 | 0.8125 | 0.8342 |