Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 20 | uM | 10581.136 | 0.7045 | 0.3142 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 100 | uM | 10581.136 | 0.4960 | -0.1372 | 0.8342 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.000256 | uM | 11854.159 | 0.9321 | 0.8918 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.00128 | uM | 11854.159 | 0.9770 | 0.9636 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.0064 | uM | 11854.159 | 0.9810 | 0.9699 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.032 | uM | 11854.159 | 0.9894 | 0.9831 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.16 | uM | 11854.159 | 0.9982 | 0.9971 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 0.8 | uM | 11854.159 | 0.9279 | 0.8850 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 4 | uM | 11854.159 | 0.9268 | 0.8833 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 20 | uM | 11854.159 | 0.7047 | 0.5163 | 1.2639 | |
| BT-20 | TNBC | Basal A | PD 98059 | MEK | MAPK | 100 | uM | 11854.159 | 0.7425 | 0.5803 | 1.2639 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 12056.159 | 0.8937 | 0.7686 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 12056.159 | 0.9019 | 0.7865 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 12056.159 | 0.9215 | 0.8291 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 12056.159 | 0.9526 | 0.8965 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 12056.159 | 0.9676 | 0.9291 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 12056.159 | 0.8727 | 0.7234 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 12056.159 | 0.9118 | 0.8080 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 12056.159 | 0.7780 | 0.5200 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 12056.159 | 0.6754 | 0.3020 | 0.9145 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 12178.159 | 1.0104 | 1.0339 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 12178.159 | 1.0028 | 1.0091 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 12178.159 | 0.9669 | 0.8931 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 12178.159 | 1.0223 | 1.0732 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 12178.159 | 1.0400 | 1.1320 | 0.6130 |