Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 12178.159 | 1.0515 | 1.1709 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 12178.159 | 1.0662 | 1.2204 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 12178.159 | 1.0239 | 1.0787 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 12178.159 | 0.8947 | 0.6681 | 0.6130 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 12291.152 | 0.9040 | 0.7239 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 12291.152 | 0.9412 | 0.8294 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 12291.152 | 1.0029 | 1.0085 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 12291.152 | 0.8627 | 0.6092 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 12291.152 | 0.9398 | 0.8253 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 12291.152 | 0.9005 | 0.7139 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 12291.152 | 0.9182 | 0.7638 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 12291.152 | 0.8840 | 0.6679 | 0.6792 | |
| BT-474 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 12291.152 | 0.7448 | 0.2961 | 0.6792 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 11855.159 | 0.9631 | 0.8848 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 11855.159 | 0.9570 | 0.8661 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 11855.159 | 0.9850 | 0.9529 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 11855.159 | 0.9829 | 0.9463 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 11855.159 | 1.0114 | 1.0361 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 11855.159 | 0.9527 | 0.8529 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 11855.159 | 0.9796 | 0.9360 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 11855.159 | 0.8850 | 0.6499 | 0.6347 | |
| BT-483 | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 11855.159 | 0.8261 | 0.4801 | 0.6347 | |
| BT-549 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.000128 | uM | 12305.152 | 0.9057 | 0.9344 | 2.9694 | |
| BT-549 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.00064 | uM | 12305.152 | 0.8903 | 0.9233 | 2.9694 | |
| BT-549 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.0032 | uM | 12305.152 | 0.9680 | 0.9782 | 2.9694 |