Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7546.066 | 1.0131 | 1.0300 | 0.8758 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7546.066 | 1.0235 | 1.0538 | 0.8758 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7546.066 | 0.9452 | 0.8753 | 0.8758 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7546.066 | 0.9186 | 0.8152 | 0.8758 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7546.066 | 0.6429 | 0.2077 | 0.8758 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7547.066 | 0.8653 | 0.7164 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7547.066 | 0.7903 | 0.5595 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7547.066 | 0.9081 | 0.8062 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7547.066 | 0.9377 | 0.8684 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7547.066 | 0.8965 | 0.7819 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7547.066 | 0.8202 | 0.6220 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7547.066 | 0.7692 | 0.5156 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7547.066 | 0.6292 | 0.2255 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7547.066 | 0.4181 | -0.2045 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10420.066 | 0.9766 | 0.9116 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10420.066 | 1.0316 | 1.1223 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10420.066 | 1.0466 | 1.1817 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10420.066 | 1.0294 | 1.1139 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10420.066 | 1.0386 | 1.1499 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10420.066 | 0.9701 | 0.8874 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10420.066 | 0.8939 | 0.6146 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10420.066 | 0.6587 | -0.0985 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10420.066 | 0.3910 | -0.6668 | 0.5240 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7552.066 | 0.9176 | 0.8380 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7552.066 | 0.9528 | 0.9073 | 1.0180 |