Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7552.066 | 0.9436 | 0.8891 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7552.066 | 0.9657 | 0.9325 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7552.066 | 0.9749 | 0.9506 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7552.066 | 0.9276 | 0.8576 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7552.066 | 0.7539 | 0.5153 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7552.066 | 0.5436 | 0.0989 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7552.066 | 0.2647 | -0.4580 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7553.066 | 0.9470 | 0.8909 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7553.066 | 0.9493 | 0.8956 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7553.066 | 0.9667 | 0.9314 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7553.066 | 0.9242 | 0.8439 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7553.066 | 0.9906 | 0.9807 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7553.066 | 0.9700 | 0.9383 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7553.066 | 0.7335 | 0.4534 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7553.066 | 0.4698 | -0.0816 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7553.066 | 0.2359 | -0.5483 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10444.066 | 0.9336 | 0.8561 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10444.066 | 1.0088 | 1.0192 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10444.066 | 0.9289 | 0.8459 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10444.066 | 0.9739 | 0.9433 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10444.066 | 0.9636 | 0.9210 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10444.066 | 0.9150 | 0.8159 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10444.066 | 0.6821 | 0.3194 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10444.066 | 0.4569 | -0.1467 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10444.066 | 0.2301 | -0.5954 | 0.9196 |