Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7511.066 | 1.1047 | 1.1778 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7511.066 | 0.9907 | 0.9841 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7511.066 | 1.0417 | 1.0712 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7511.066 | 0.9062 | 0.8385 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7511.066 | 0.6399 | 0.3652 | 1.1691 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7512.066 | 1.0829 | 1.1933 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7512.066 | 1.1056 | 1.2467 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7512.066 | 1.0344 | 1.0800 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7512.066 | 0.9703 | 0.9313 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7512.066 | 1.0687 | 1.1600 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7512.066 | 0.9229 | 0.8225 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7512.066 | 0.9226 | 0.8218 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7512.066 | 0.9278 | 0.8336 | 0.8629 | |
| MDA-MB-415 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7512.066 | 0.5011 | -0.1020 | 0.8629 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7515.066 | 0.8359 | 0.7246 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7515.066 | 0.8255 | 0.7068 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7515.066 | 0.8827 | 0.8040 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7515.066 | 0.8812 | 0.8015 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7515.066 | 0.9212 | 0.8688 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7515.066 | 0.8245 | 0.7051 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7515.066 | 0.8478 | 0.7448 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7515.066 | 0.8483 | 0.7458 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7515.066 | 0.5264 | 0.1769 | 1.2099 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7516.066 | 0.9087 | 0.8459 | 1.1944 | |
| MDA-MB-453 | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7516.066 | 0.9810 | 0.9681 | 1.1944 |