Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7555.066 | 0.9425 | 0.9318 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7555.066 | 0.9325 | 0.9198 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7555.066 | 0.9445 | 0.9343 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7555.066 | 0.9470 | 0.9372 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7555.066 | 0.9785 | 0.9748 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7555.066 | 0.8455 | 0.8129 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7555.066 | 0.5924 | 0.4720 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7555.066 | 0.3854 | 0.1445 | 1.7081 | |
| ZR75B | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7555.066 | 0.3423 | 0.0678 | 1.7081 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12509.147 | 1.0871 | 1.1433 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12509.147 | 1.0815 | 1.1342 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12509.147 | 1.0527 | 1.0871 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12509.147 | 1.1096 | 1.1802 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12509.147 | 1.1258 | 1.2065 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12509.147 | 0.9756 | 0.9594 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12509.147 | 0.4998 | 0.1251 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12509.147 | 0.2872 | -0.2893 | 1.2058 | |
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 133 | uM | 12509.147 | 0.2610 | -0.3436 | 1.2058 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12566.147 | 1.0273 | 1.0336 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12566.147 | 1.0220 | 1.0271 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12566.147 | 1.0240 | 1.0295 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12566.147 | 1.0770 | 1.0939 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12566.147 | 0.9754 | 0.9694 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12566.147 | 0.7984 | 0.7400 | 1.6169 | |
| 184B5 | NM | Basal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12566.147 | 0.5521 | 0.3850 | 1.6169 |